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KMID : 0604519990250010068
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Journal of the Society of Cosmetic Scientists of Korea
1999 Volume.25 No. 1 p.68 ~ p.88
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The Effects of Alpinia katsumadai Extract on Anti-inflammation and Melanogenesis
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이재섭/Jae Soeb Lee
정시화/고강일/김기호/정점규/박수남/See-Hwa Jeong/Kang-Il Ko/Ki Ho Kim/Chom-Kyu Chong/Soo Nam Park
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Abstract
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Several solvent extracts from alpinia katsumadai were prepared and their various
anti-inflammatory effects among the 8 medicinal plant extracts. Butanol extract from
Alpinia katsumadai showed a potent anti-oxidative and free radical scavenging activities.
Free radical scavenging effect of butanol fraction of Alpinia
katsumadai(IC50 : 5㎍/㎖) was higher than butylated
hydroxytoluene(IC50 : 50㎍/㎖) and ascorbic acid (IC50 : 22㎍
/㎖). Alpinia katsumadai ethanol extract on elastase exhibited 10 to 78％ at 100 to 1000
㎍/㎖ concentration ; the IC50 values with 465.7㎍/㎖ for porcine pancreatic
elastase(PPE) and 481.9㎍/㎖ for human leukocyte elastase(HLE), respectively. The
Alpinia katsumadai extract inhibited effectively hyaluronidase activity(IC50
: 335㎍/㎖), and showed inhibition in vitro on delayed hypersensitivity when it was
topically applied. These results suggest that Alpinia katsumadai extract may reduce
inflammatory skin trouble. The Alpinia katsumadai extract also showed higher inhibitory
effect of melanin biosynthesis on cultured melanoma cell compared to arbuitn and kojic
acid.
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